The role of vehicle interactions on permeation of an active through model membranes and human skin

Previous work from this group has focused on the molecular mechanism of alcohol interaction with model membranes, by conducting thermodynamic and kinetic analyses of alcohol uptake, membrane partitioning and transport studies of a model compound (i.e. methyl paraben) in silicone membranes. In this article, similar membrane transport and partitioning studies were conducted in silicone membranes to further extend the proposed model of alcohol interactions with silicone membranes to include other vehicles more commonly used in dermal formulations, that is, isopropyl myristate (IPM), dimethyl isosorbide (DMI), polyethylene glycol (PEG) 200, PEG 400 and Transcutol P^® (TC). More importantly, membrane partitioning studies were conducted using human SC to evaluate the application of the proposed model of solvent‐enhanced permeation in simple model membranes for the more complex biological tissue. The findings support a model of vehicle interactions with model membranes and skin where high solvent uptake promotes drug partitioning (i.e. K) by enabling the solute to exist within the solvent fraction/solvent‐rich areas inside the membrane or skin in a concentration equivalent to that in the bulk solvent/vehicle. High solvent sorption may also ultimately impact on the membrane diffusional characteristics, and thus the diffusion coefficient of the solute across the membrane. The implications for skin transport are that increased partitioning of a drug into the SC may be achieved by (i) selecting vehicles that are highly taken up by the skin and also (ii) by having a relatively high concentration (i.e. molar fraction) of the drug in the vehicle. It follows that, in cases where significant co‐transport of the solvent into and across the skin may occur, its depletion from the formulation and ultimately from the skin may lead to drug crystallization, thus affecting dermal absorption.     

标准化的发展阶段划分新论

本文阐述了标准化的起源及其里程碑标志，分析了标准化发展阶段的传统划分方式和特点，提出了用标准化的推动力属性划分标准化发展阶段的新概念，详细论述了标准化发展阶段划分的新方式及其特点，对标准化发展的未来阶段进行了预测。     

Comment on 'Active simulation of grounded inductors with CCII+ s and grounded passive elements'

This comment shows that circuits for active simulation of grounded inductors with plus-type second-generation current-conveyors (CCII + s) and grounded passive elements can be systematically derived from Sedra-Smith gyrator realization. In addition to the available realizations, new circuit topologies are presented. Some of the new topologies can yield inductance forms which are not realizable using the available topologies. Also, a new topology for realizing pure inductance without recourse to element matching conditions is presented.     

划分系数与归一化型的比较研究

对J C .Bezdek提出的划分系数 ,基于样本最大分类信息的改进划分系数 ,以及二者的归一化形式的分类性能进行了实验分析 ,结果表明 ,归一化处理的分类性能有明显提高。     

SBC120聚乙烯丙纶复合防水卷材在屋面工程中的应用

介绍了SBC 12 0聚乙烯丙纶复合防水卷材的结构、特点及应用 ,主要阐述了防水卷材的应用方法和注意事项。     

Image Segmentation via Iterative Fuzzy Clustering Based on Local Space-Frequency Multi-Feature Coherence Criteria

Fuzzy set theory has recently attracted much attention in the field of image classification, image understanding and image processing. One of the major topics in fuzzy image processing is the image classification problem. This paper presents a fast and accurate iterative fuzzy clustering (I.F.C.) method dynamically adapted to the classification process. This is used for high performance fuzzy segmentation which forms the basis for reliable image understanding. The proposed fuzzy segmentation scheme examines the image connectivity in the space and frequency domains. The detected fuzzy features are combined via a block synthesis and local correlation algorithmic procedure. Some results showing that the performance of the proposed I.F.C./clustering method is superior from that of the standard fuzzy c-means method are provided.     

COSMO‐RS Calculations of Partition Coefficients: Different Tools for Conformation Search

This work is encouraged by the growing interest and recent success of quantum mechanics‐based methods in modeling of thermodynamic properties in the field of chemical engineering and life sciences. Among those, the COSMO‐RS model has become one of the most popular methods to predict phase equilibria in complex bio‐related systems. Recently, we have shown that the quality of predictions of n‐octanol/water and micelle/water partition coefficients is improved when the weighted mixtures of conformers are used to represent molecules, thereby demanding that the conformation analysis is performed for each component of the system. In this paper, different methods for performing the conformational search are evaluated. Micelle/water partition coefficients of solutes from different homologous series in aqueous solutions of Triton X100 as well as the n‐octanol/water partitioning of three common drugs (aminopinicillanic acid, ampicillin, and penicillin G) are calculated and compared with experimental data. Conformational analysis is made by the HyperChem program for the molecules placed in vacuum as well as by using the molecular dynamics simulation in a solvent medium (n‐octanol and water). It is demonstrated that molecular dynamics simulation is a promising tool to conduct conformational analysis. Along with the possibility of providing the conformers for large surfactant and pharmaceutical molecules, the method accounts for the solvent in a realistic manner. The results for micelle/water partition coefficients illustrate that n‐octanol is a reasonable approximation for the “micelle‐like” medium in molecular dynamics (MD) simulations. Predicted n‐octanol/water partition coefficients of three penicillins are in a good agreement with literature data and values calculated by a common quantitative structure‐activity relationship (QSAR).     

碱矿渣水泥—赤泥基轻质隔墙板的研究

研究了碱矿渣水泥－赤泥基轻质隔墙板的组成和性能。使用碱矿渣水泥激发剂Ａ和Ｂ，采用正交法确定了各组分材料的最佳配比。在最佳配比条件下，试制出了性能优良的轻质墙板，其抗折力达到１６００Ｎ，面密度小于６０ｋｇ／ｍ２，具有较好的经济、社会效益。     

PARTITIONING OF π-ELECTRONS IN RINGS OF POLYCYCLIC conjugated HYDROCARBONS. PART 1: CATACONDENSED BENZENOIDS

Recently a novel view on Kekulé valence structures (or resonance structures) was reported in which their standard geometrical representation was replaced by a numerical representation obtained by assigning π-electrons associated with CC double bonds to individual benzenoid rings. In the present article, we examine in more detail the partitioning of π-electrons to benzenoid rings for cata-condensed benzenoid hydrocarbons. For special families of cata-condensed benzenoids, we offer formulas which allow one to obtain the average π-electron ring content for individual benzenoid rings of polycyclic conjugated hydrocarbons. We also show that the average π-electron ring content for individual benzenoid rings can be calculated from Pauling bond orders without a need to examine all Kekulé resonance structures of a molecule.     

Mass transfer and separation criteria for high‐speed countercurrent chromatography

High‐speed countercurrent chromatography (HSCCC) is a versatile technique for preparative separations of a wide variety of solutes. For optimization of operating conditions, prediction of separations, and scale‐up study, a model is needed to describe the effluent concentration profile, which determines the separation efficiency (mass transfer, mixing, and partitioning) and the resolution between peaks. A transfer‐dispersive model is proposed to describe the effluent profile based on the assumption that the retention of a peak is caused by partitioning over two phases, and peak broadening is caused by axial dispersion and mass transfer limitation. In this work, mass transfer was investigated by comparing model simulations to experimental data. One generalized correlation of overall mass transfer coefficients was derived. Based on the correlations of axial dispersion coefficients in our previous work and mass transfer coefficients in this study, the model predicts the elution concentration profile well. Furthermore, separation criteria were proposed to predict the separation of two adjacent solutes, and they were verified using literature data. © 2010 American Institute of Chemical Engineers AIChE J, 2011